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We also established two popular therapeutic models PD-1 monoclonal antibody (mAb) injection and whole cancer cell vaccine (WCV) injection in fibrosarcoma-allografted mice (PD-1 group and WCV group) in parallel to facilitate the discovery process

Treatment with the combination according to the invention invariably yielded statistically significantly superior results as compared to the group treated with sildenafil alone in the tests reported in Tables 1- 10